Clustered microRNAs' coordination in regulating protein-protein interaction network

doi:10.1186/1752-0509-3-65

	Clustered microRNAs' coordination in regulating protein-protein interaction network
	Yuan, Xiongying 1,2; Liu, Changning 1; Yang, Pengcheng 1,2; He, Shunmin 1,2; Liao, Qi 1,3; Kang, Shuli 1; Zhao, Yi 1
	2009-06-26
发表期刊	BMC SYSTEMS BIOLOGY
ISSN	1752-0509
卷号	3 页码:10
摘要	Background: MicroRNAs (miRNAs), a growing class of small RNAs with crucial regulatory roles at the post-transcriptional level, are usually found to be clustered on chromosomes. However, with the exception of a few individual cases, so far little is known about the functional consequence of this conserved clustering of miRNA loci. In animal genomes such clusters often contain non-homologous miRNA genes. One hypothesis to explain this heterogeneity suggests that clustered miRNAs are functionally related by virtue of co-targeting downstream pathways. Results: Integrating of miRNA cluster information with protein protein interaction (PPI) network data, our research supports the hypothesis of the functional coordination of clustered miRNAs and links it to the topological features of miRNAs' targets in PPI network. Specifically, our results demonstrate that clustered miRNAs jointly regulate proteins in close proximity of the PPI network. The possibility that two proteins yield to this coordinated regulation is negatively correlated with their distance in PPI network. Guided by the knowledge of this preference, we found several network communities enriched with target genes of miRNA clusters. In addition, our results demonstrate that the variance of this propensity can also partly be explained by protein's connectivity and miRNA's conservation. Conclusion: In summary, this work supports the hypothesis of intra-cluster coordination and investigates the extent of this coordination.
DOI	10.1186/1752-0509-3-65
收录类别	SCI
语种	英语
资助项目	National Sciences Foundation of China[30570393] ; National Sciences Foundation of China[30600729]
WOS研究方向	Mathematical & Computational Biology
WOS类目	Mathematical & Computational Biology
WOS记录号	WOS:000268816600001
出版者	BIOMED CENTRAL LTD
引用统计	被引频次：101[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11630
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Zhao, Yi
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Ctr Adv Comp Res, Bioinformat Grp, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Sun Yat Sen Univ, Dept Parasitol, Zhongshan Sch Med, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiongying,Liu, Changning,Yang, Pengcheng,et al. Clustered microRNAs' coordination in regulating protein-protein interaction network[J]. BMC SYSTEMS BIOLOGY,2009,3:10.
APA	Yuan, Xiongying.,Liu, Changning.,Yang, Pengcheng.,He, Shunmin.,Liao, Qi.,...&Zhao, Yi.(2009).Clustered microRNAs' coordination in regulating protein-protein interaction network.BMC SYSTEMS BIOLOGY,3,10.
MLA	Yuan, Xiongying,et al."Clustered microRNAs' coordination in regulating protein-protein interaction network".BMC SYSTEMS BIOLOGY 3(2009):10.