Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae

	Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae
	Chen Lan 1,2; Cai Lun 1,2; Geir Skogerb 3; Chen Run-Sheng 1,3
	2008
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	35 期号:1 页码:35-42
摘要	Collaboration networks have proven informative when used to describe various kinds of human relationships. Similar strategy could be used in the transcriptional regulatory network. A collaboration network of target genes (TGs) was constructed based on common transcription factors (TFs), and similarly, a smaller network of transcription factors was constructed based on their common target genes. After clustering the target gene collaboration networks, genes in the same cluster were often enriched for one or more GO terms. The results also showed that genes with specific GO terms tend to share similar regulatory mechanisms. It indicates that in a collaboration network approach the relatively simple "regulatory mechanism" measure used here was able to extract considerable biologically relevant information. Moreover, a definition of anomaly used before in a bipartite graph analysis method was applied into the collaboration networks analysis. And the correlation between the anomalies and the essential genes was discovered. In a conclusion, a collaboration network approach may be a valuable supplement to other analyses of transcriptional networks.
关键词	transcriptional regulatory network collaboration network anomaly
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000254046500005
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11380
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen Run-Sheng
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Bioinformat Lab, Inst Biophys, Beijing 1000101, Peoples R China
推荐引用方式 GB/T 7714	Chen Lan,Cai Lun,Geir Skogerb,et al. Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2008,35(1):35-42.
APA	Chen Lan,Cai Lun,Geir Skogerb,&Chen Run-Sheng.(2008).Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,35(1),35-42.
MLA	Chen Lan,et al."Analysis of transcriptional regulation collaboration networks in Saccharomy cescerevisiae".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35.1(2008):35-42.