The epidemic origin and molecular properties of B ': a founder strain of the HIV-1 transmission in Asia

doi:10.1097/QAD.0b013e32830f4c62

	The epidemic origin and molecular properties of B ': a founder strain of the HIV-1 transmission in Asia
	Deng, Xiang ; Liu, Haizhou 2; Shao, Yiming 3,4; Rayner, Simon 2; Yang, Rongge 1
	2008-09-12
发表期刊	AIDS
ISSN	0269-9370
卷号	22 期号:14 页码:1851-1858
摘要	Objective: To clarify the epidemic origin and molecular properties of the B' subtype that is an important strain in the HIV-1 epidemic in Asia. Design: The genealogical relationship between the B' and B subtype was investigated with two globally representative datasets covering the gag and env regions. B' sequences were identified, from which the epidemic origin, population genetics and the signature mutation sites of the B' subtype were inferred. Methods: Two globally representative datasets were compiled, using phylogenetic methods. Through coalescent-based analysis, the genealogical relationship between the B' and B subtypes was investigated. The divergence times and population genetic parameters of B' were estimated in a Bayesian framework using Markov Chains Monte Carlo sampling under a relaxed molecular clock method. Additionally, molecular properties of the B' were identified by performing comparative sequence analysis with the HIV-1 M group. Results: About 15 years later after the B subtype began to spread, the B' diverged from the B subtype. The demographic history of B' was reconstructed, and the epidemic of B' was estimated to originate around 1985. Eight and nine distinct signature mutation sites, unique to B', were found around the p17 and V3 regions, respectively. Conclusion: Our research is the first large-scale investigation on HIV-1 B' at a global level and provides a deep insight into one of the founder strains of HIV-1 epidemic in Asia. Our results provide an important reference for HIV scientists, public health officials and HIV vaccine designers. (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
关键词	Asia B' B subtype evolution HIV-1 molecular epidemiology Thai-B
DOI	10.1097/QAD.0b013e32830f4c62
收录类别	SCI
语种	英语
资助项目	One Hundred Intellectual Project of The Chinese Academy of Sciences[0702291YC1] ; National Basic Research 973 Program of China[2005CB522903] ; National Basic Research 973 Program of China[2006CB504200]
WOS研究方向	Immunology ; Infectious Diseases ; Virology
WOS类目	Immunology ; Infectious Diseases ; Virology
WOS记录号	WOS:000259546700020
出版者	LIPPINCOTT WILLIAMS & WILKINS
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11281
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yang, Rongge
作者单位	1.Chinese Acad Sci, HIV Mol Epidemiol & Virol Res Grp, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 2.Chinese Acad Sci, Bioinformat Res Grp, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Beijing, Peoples R China 4.Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xiang,Liu, Haizhou,Shao, Yiming,et al. The epidemic origin and molecular properties of B ': a founder strain of the HIV-1 transmission in Asia[J]. AIDS,2008,22(14):1851-1858.
APA	Deng, Xiang,Liu, Haizhou,Shao, Yiming,Rayner, Simon,&Yang, Rongge.(2008).The epidemic origin and molecular properties of B ': a founder strain of the HIV-1 transmission in Asia.AIDS,22(14),1851-1858.
MLA	Deng, Xiang,et al."The epidemic origin and molecular properties of B ': a founder strain of the HIV-1 transmission in Asia".AIDS 22.14(2008):1851-1858.