GC content variability of eubacteria is governed by the pol III alpha subunit

doi:10.1016/j.bbrc.2007.02.109

	GC content variability of eubacteria is governed by the pol III alpha subunit
	Zhao, Xiaoqian ; Zhang, Zhang ; Yan, Jiangwei ; Yu, Jun
	2007-04-27
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	356 期号:1 页码:20-25
摘要	Eubacterial genomes have highly variable GC content (0.17-0.75) and the primary mechanism of such variability remains unknown. The place to look for is what actually catalyzes the synthesis of DNA, where DNA polymerase III is at the center stage, particularly one of its 10 subunits-the alpha subunit. According to the dimeric combination of a subunits, GC contents of eubacterial genomes were partitioned into three groups with distinct GC content variation spectra: dnaE1 (full-spectrum), dnaE2/dnaE1 (high-GC), and polC/dnaE3 (low-GC). Therefore, genomic GC content variability is believed to be governed primarily by the alpha subunit grouping of DNA polymerase III; it is of essence in genome composition analysis to take full account of such a grouping principle. Since horizontal gene transfer is very frequent among bacterial genomes, exceptions of the grouping scheme, a few percents of the total, are readily identifiable and should be excluded from in-depth analyses on nucleotide compositions. (c) 2007 Elsevier Inc. All rights reserved.
关键词	genomic GC content DNA polymerase III alpha subunit dnaE polC
DOI	10.1016/j.bbrc.2007.02.109
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000245419300004
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/11059
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yu, Jun
作者单位	1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 101300, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xiaoqian,Zhang, Zhang,Yan, Jiangwei,et al. GC content variability of eubacteria is governed by the pol III alpha subunit[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,356(1):20-25.
APA	Zhao, Xiaoqian,Zhang, Zhang,Yan, Jiangwei,&Yu, Jun.(2007).GC content variability of eubacteria is governed by the pol III alpha subunit.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,356(1),20-25.
MLA	Zhao, Xiaoqian,et al."GC content variability of eubacteria is governed by the pol III alpha subunit".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356.1(2007):20-25.