Compositional dynamics of guanine and cytosine content in prokaryotic genomes

doi:10.1016/j.resmic.2007.02.007

	Compositional dynamics of guanine and cytosine content in prokaryotic genomes
	Hu, Jianfei ; Zhao, Xiaoqian ; Zhang, Zhang ; Yu, Jun
	2007-05-01
发表期刊	RESEARCH IN MICROBIOLOGY
ISSN	0923-2508
卷号	158 期号:4 页码:363-370
摘要	Nucleotide compositional analyses of disparities in genomic guanine and cytosine (gGC) content directly relate to the amino acid composition, through the union of the genetic code. Here we analyzed 229 prokaryotic genomes to address the intricate relationships between gGC, amino acids and their codons in the context of genes. First, we not only confirmed the universal rule that the average GC content at codon position 1 (GC1) is always higher than that at codon position 2 (GC2), but also extended the rule to show that it holds true even when codon-position-related GC contents are calculated on a per gene basis. The "GC1 > GC2 rule" is attributable essentially to a few dominant amino acids that have GC at one of these two codon positions or the intermediate-GC group of amino acids. Second, we found that gGC fluctuations were largely compensated for at the codon level, when codons belonging to high-GC and low-GC amino acid groups varied accordingly. Finally, we found that prokaryotic genes also have a GC content gradient (Gd) distributed along their transcripts. The gradients at three codon positions (Gd1, Gd2 and Gd3) all correlated with gGC in two different directions: Gd3 was positive, whereas the other two were negative. (c) 2007 Elsevier Masson SAS. All rights reserved.
关键词	genomic GC content (gGC) codon positions (GC1, GC2 and GC3) GC content gradient (Gd)
DOI	10.1016/j.resmic.2007.02.007
收录类别	SCI
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000247771700008
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/10996
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Yu, Jun
作者单位	1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 101300, Peoples R China 2.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 5.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Peoples R China
推荐引用方式 GB/T 7714	Hu, Jianfei,Zhao, Xiaoqian,Zhang, Zhang,et al. Compositional dynamics of guanine and cytosine content in prokaryotic genomes[J]. RESEARCH IN MICROBIOLOGY,2007,158(4):363-370.
APA	Hu, Jianfei,Zhao, Xiaoqian,Zhang, Zhang,&Yu, Jun.(2007).Compositional dynamics of guanine and cytosine content in prokaryotic genomes.RESEARCH IN MICROBIOLOGY,158(4),363-370.
MLA	Hu, Jianfei,et al."Compositional dynamics of guanine and cytosine content in prokaryotic genomes".RESEARCH IN MICROBIOLOGY 158.4(2007):363-370.