Predicting protein function based on modularized protein interaction network

	Predicting protein function based on modularized protein interaction network
	Lu, HC ; Shi, QY ; Shi, BC ; Zhang, ZH ; Zhao, Y ; Tang, SQ ; Xiong, L ; Wang, Q ; Chen, RS
	2006-05-01
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	33 期号:5 页码:446-451
摘要	In the post-genomics era in which gene sequences have been decoded, large-scale protein-protein interaction data are generated with the rapid development of system biology experiments. It is important in functional genomics to search for function modules and predict protein functions from the data. A new method called modularized clustering method (MCM), which are based on the direct and second-order interactions of modules, is applied to the latest high-throughput protein-protein network of yeast to predict the function of unknown proteins in the modules. P value of hypergeometric cumulative distribution of modules and the disturbance analysis on the data, including adding, removing and rewiring interactions, are employed to evaluate the prediction quality and robustness of the method. The results show that MCM has high prediction precise rate and coverage, and it is robust to high false-positive data and missing data. The predicted results of unknown proteins with high prediction precise rate can be instructive in biological analysis and the algorithm can be generalized to other networks with the similar structures.
关键词	protein-protein interaction network predicting function of proteins clustering
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000237610400006
出版者	SCIENCE CHINA PRESS
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/10784
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Wang, Q
作者单位	1.Guangxi Normal Univ, Coll Phys & Informat Engn, Guilin, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lu, HC,Shi, QY,Shi, BC,et al. Predicting protein function based on modularized protein interaction network[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(5):446-451.
APA	Lu, HC.,Shi, QY.,Shi, BC.,Zhang, ZH.,Zhao, Y.,...&Chen, RS.(2006).Predicting protein function based on modularized protein interaction network.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(5),446-451.
MLA	Lu, HC,et al."Predicting protein function based on modularized protein interaction network".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.5(2006):446-451.