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Predicting protein function based on modularized protein interaction network
Lu, HC; Shi, QY; Shi, BC; Zhang, ZH; Zhao, Y; Tang, SQ; Xiong, L; Wang, Q; Chen, RS
2006-05-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
卷号33期号:5页码:446-451
摘要In the post-genomics era in which gene sequences have been decoded, large-scale protein-protein interaction data are generated with the rapid development of system biology experiments. It is important in functional genomics to search for function modules and predict protein functions from the data. A new method called modularized clustering method (MCM), which are based on the direct and second-order interactions of modules, is applied to the latest high-throughput protein-protein network of yeast to predict the function of unknown proteins in the modules. P value of hypergeometric cumulative distribution of modules and the disturbance analysis on the data, including adding, removing and rewiring interactions, are employed to evaluate the prediction quality and robustness of the method. The results show that MCM has high prediction precise rate and coverage, and it is robust to high false-positive data and missing data. The predicted results of unknown proteins with high prediction precise rate can be instructive in biological analysis and the algorithm can be generalized to other networks with the similar structures.
关键词protein-protein interaction network predicting function of proteins clustering
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000237610400006
出版者SCIENCE CHINA PRESS
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文献类型期刊论文
条目标识符http://119.78.100.204/handle/2XEOYT63/10784
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Wang, Q
作者单位1.Guangxi Normal Univ, Coll Phys & Informat Engn, Guilin, Peoples R China
2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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GB/T 7714
Lu, HC,Shi, QY,Shi, BC,et al. Predicting protein function based on modularized protein interaction network[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(5):446-451.
APA Lu, HC.,Shi, QY.,Shi, BC.,Zhang, ZH.,Zhao, Y.,...&Chen, RS.(2006).Predicting protein function based on modularized protein interaction network.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(5),446-451.
MLA Lu, HC,et al."Predicting protein function based on modularized protein interaction network".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.5(2006):446-451.
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