Integrated analysis of multiple data sources reveals modular structure of biological networks

doi:10.1016/j.bbrc.2006.04.088

	Integrated analysis of multiple data sources reveals modular structure of biological networks
	Lu, HC ; Shi, BC ; Wu, GW ; Zhang, Y ; Zhu, XP ; Zhang, ZH ; Liu, CN ; Zhao, Y ; Wu, T ; Wang, J ; Chen, RS
	2006-06-23
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	345 期号:1 页码:302-309
摘要	It has been a challenging task to integrate high-throughput data into investigations of the systematic and dynamic organization of biological networks. Here, we presented a simple hierarchical clustering algorithm that goes a long way to achieve this aim. Our method effectively reveals the modular structure of the yeast protein-protein interaction network and distinguishes protein complexes from functional modules by integrating high-throughput protein-protein interaction data with the added subcellular localization and expression profile data. Furthermore, we take advantage of the detected modules to provide a reliably functional context for the uncharacterized components within modules. On the other hand, the integration of various protein-protein association information makes our method robust to false-positives, especially for derived protein complexes. More importantly, this simple method can be extended naturally to other types of data fusion and provides a framework for the study of more comprehensive properties of the biological network and other forms of complex networks. (c) 2006 Elsevier Inc. All rights reserved.
关键词	integrated analysis of multiple data sources hierarchical clustering algorithm protein-protein interaction network modular structure of biological networks
DOI	10.1016/j.bbrc.2006.04.088
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000237877700042
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/10553
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, RS
作者单位	1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Lu, HC,Shi, BC,Wu, GW,et al. Integrated analysis of multiple data sources reveals modular structure of biological networks[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,345(1):302-309.
APA	Lu, HC.,Shi, BC.,Wu, GW.,Zhang, Y.,Zhu, XP.,...&Chen, RS.(2006).Integrated analysis of multiple data sources reveals modular structure of biological networks.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(1),302-309.
MLA	Lu, HC,et al."Integrated analysis of multiple data sources reveals modular structure of biological networks".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345.1(2006):302-309.