Conserved distances between vertebrate highly conserved elements

doi:10.1093/hmg/ddl232

	Conserved distances between vertebrate highly conserved elements
	Sun, Hong ; Skogerbo, Geir ; Chen, Runsheng
	2006-10-01
发表期刊	HUMAN MOLECULAR GENETICS
ISSN	0964-6906
卷号	15 期号:19 页码:2911-2922
摘要	High numbers of sequence element with very high (> 95%) sequence conservation between the human and other vertebrate genomes have been reported and ascribed putative cis-regulatory functions. We have investigated the structural relationships between such elements in mammalian genomes and find that not only their sequences, but also the distances between them are significantly (P < 2.2x10(-16)) more conserved than corresponding distances between orthologous protein-coding genes or between exons within these genes. Regions of largely conserved distance between consecutive highly conserved elements (HCE) generally overlap previously identified HCE clusters, but may be far longer (up to 20 Mb) and possibly cover close to 25% of the human genome sequence. Similar conservation of distance is found between bird (chicken) and mammalian genomes and is also discernible in comparisons between fish and mammals. The data suggest either that a substantial amount of essential (functionally active) elements with lower sequence conservation occupy the space between the HCEs or that distance itself is an important factor in transcriptional regulation or chromatin modelling.
DOI	10.1093/hmg/ddl232
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000240696100008
出版者	OXFORD UNIV PRESS
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/10442
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, Runsheng
作者单位	1.Chinese Acad Sci, Bioinformat Lab, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Natl Lab Biomacromol, Inst Biophys, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Sun, Hong,Skogerbo, Geir,Chen, Runsheng. Conserved distances between vertebrate highly conserved elements[J]. HUMAN MOLECULAR GENETICS,2006,15(19):2911-2922.
APA	Sun, Hong,Skogerbo, Geir,&Chen, Runsheng.(2006).Conserved distances between vertebrate highly conserved elements.HUMAN MOLECULAR GENETICS,15(19),2911-2922.
MLA	Sun, Hong,et al."Conserved distances between vertebrate highly conserved elements".HUMAN MOLECULAR GENETICS 15.19(2006):2911-2922.