Genome-wide analysis of mammalian DNA segment fusion/fission

doi:10.1016/j.jtbi.2005.09.016

	Genome-wide analysis of mammalian DNA segment fusion/fission
	Zhang, Zhihua ; Sun, Hong ; Zhang, Yong ; Zhao, Yi ; Shi, Baochen ; Sun, Shiwei ; Lu, Hongchao ; Bu, Dongbo ; Ling, Lunjiang ; Chen, Runsheng
	2006-05-21
发表期刊	JOURNAL OF THEORETICAL BIOLOGY
ISSN	0022-5193
卷号	240 期号:2 页码:200-208
摘要	As a powerful tool for gene function prediction, gene fusion has been widely studied in prokaryotes and certain groups of eukaryotes, but it has been little applied in studies of mammalian genomes. With the first fully sequenced mammalian genomes (human, mouse, rat) now available, we defined and collected a set of fusion/fission event-linked segments (FFLS) based on structured organized genomic alignment. The statistics of the sequence features highlighted the FFLSs against their random context. We found that there are three groups of FFLSs with different component pairs (i.e. gene-gene, gene-noncoding and noncoding-noncoding) in all three mammalian genomes. The proteins encoded by the components of FFLSs in the first group shown a strong tendency to interact with each other. The segmental components in the last two groups which did not contain any protein-coding genes, were found not only to be transcribed to some level, but also more conserved than the random background. Thus, these segments are possibly carrying certain biologically functional elements. We propose that FFLS may be a potential tool for prediction and analysis of function and functional interaction of genetic elements, including both genes and noncoding elements, in mammalian genomes. The full list of the FFLSs in the genomes of the three mammals is available as supporting information at doi:10.1016/j.jtbi.2005.09.016. (c) 2005 Elsevier Ltd. All rights reserved.
关键词	fusion fission mammalian comparative genomic non-protein coding DNA segment
DOI	10.1016/j.jtbi.2005.09.016
收录类别	SCI
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS类目	Biology ; Mathematical & Computational Biology
WOS记录号	WOS:000237828200004
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.204/handle/2XEOYT63/10349
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, Runsheng
作者单位	1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Acad Sinica, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Comp Technol, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhihua,Sun, Hong,Zhang, Yong,et al. Genome-wide analysis of mammalian DNA segment fusion/fission[J]. JOURNAL OF THEORETICAL BIOLOGY,2006,240(2):200-208.
APA	Zhang, Zhihua.,Sun, Hong.,Zhang, Yong.,Zhao, Yi.,Shi, Baochen.,...&Chen, Runsheng.(2006).Genome-wide analysis of mammalian DNA segment fusion/fission.JOURNAL OF THEORETICAL BIOLOGY,240(2),200-208.
MLA	Zhang, Zhihua,et al."Genome-wide analysis of mammalian DNA segment fusion/fission".JOURNAL OF THEORETICAL BIOLOGY 240.2(2006):200-208.